For example, the optimum pH for pepsin, an enzyme that is active in the stomach, is 2.0.\)). However, a few enzymes have optimum pH values outside this range. Not surprisingly, most enzymes exhibit optimal activity in this pH range. With the notable exception of gastric juice (the fluids secreted in the stomach), most body fluids have pH values between 6 and 8. of the enzyme (part (b) of Figure 18.14 "Temperature and pH versus Concentration"). The median value of this pH range is called the optimum pH The pH at which a particular enzyme exhibits maximum activity. Neutralization of even one of these charges alters an enzyme’s catalytic activity.Īn enzyme exhibits maximum activity over the narrow pH range in which a molecule exists in its properly charged form. Ionizable side groups located in the active site must have a certain charge for the enzyme to bind its substrate. Enzymes may be denatured by extreme levels of hydrogen ions (whether high or low) any change in pH, even a small one, alters the degree of ionization of an enzyme’s acidic and basic side groups and the substrate components as well.
zip file containing this book to use offline, simply click here.īecause most enzymes are proteins, they are sensitive to changes in the hydrogen ion concentration or pH. You can browse or download additional books there. More information is available on this project's attribution page.įor more information on the source of this book, or why it is available for free, please see the project's home page. Additionally, per the publisher's request, their name has been removed in some passages. However, the publisher has asked for the customary Creative Commons attribution to the original publisher, authors, title, and book URI to be removed. Normally, the author and publisher would be credited here. This content was accessible as of December 29, 2012, and it was downloaded then by Andy Schmitz in an effort to preserve the availability of this book. See the license for more details, but that basically means you can share this book as long as you credit the author (but see below), don't make money from it, and do make it available to everyone else under the same terms. This book is licensed under a Creative Commons by-nc-sa 3.0 license.
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